Department of Chemistry and Biochemistry

Dr. Edith Glazer, associate Professor, from the University of Kentucky will present a seminar titled: "Targeting DNA (and other things) with metal complexes". Many cytotoxic metal complexes interact with or damage DNA. While this provides for effective cell killing, the non-selective mechanism leads to potential off-target effects. A promising approach is to develop compounds capable of targeting and damaging key biological molecules, such as specific nucleic acid structures, sequences, or proteins. However, unless highly potent (nM activity) compounds are identified, [...]