Ayanjeet Ghosh

Ayanjeet Ghosh

Assistant Professor


  • Postdoctoral Associate, University of Illinois, 2016-2018
  • Postdoctoral Associate, University of Wisconsin, 2014-2016
  • Postdoctoral Associate, University of Pennsylvania, 2012-2013
  • PhD, University of Pennsylvania, 2012
  • MSc, Indian Institute of Technology, Kanpur, 2006
  • BSc, University of Calcutta, 2005


The central premise of Dr. Ghosh’s research is to employ infrared spectroscopy as a means to provide chemical contrast in optical and atomic force microscopy. Research in Dr. Ghosh’s group will seek to extend the unique capabilities of infrared spectroscopy towards molecular imaging, and push the boundaries of existing technology through development and application of novel infrared microscopies towards problems of major societal importance, such as cancer diagnostics and design of better solar cell materials.

Selected Publications

Ghosh A, Ostrander JS and Zanni MT. Watching Proteins Wiggle: Mapping Structures with Two-Dimensional Infrared Spectroscopy. Chemical Reviews, 2017, 117, 10726–10759.

Ostrander JS, Serrano AL, Ghosh A and Zanni MT. Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy. ACS Photonics, 2016, 3, 1315–1323.

Ghosh A*, Serrano AL*, Oudenhoven TA, Ostrander JS, Eklund EC, Blair AF, and Zanni MT. Experimental implementations of 2D IR spectroscopy through a horizontal pulse shaper design and a focal plane array detector. Optics Letters, 2016, 41, 524-527.

Ho J , Skoff DR, Ghosh A and Zanni MT. Structural Characterization of Single-Stranded DNA Monolayers Using Two-Dimensional Sum Frequency Generation Spectroscopy. Journal of Physical Chemistry B, 2015, 119, 10586-10596.

Serrano AL*, Ghosh A*, Ostrander JS, Zanni MT. Wide-field FTIR Microscopy using Mid-IR Pulse Shaping. Optics Express, 2015, 23, 17815-17827.

Ghosh A , Ho J, Serrano AL, Skoff DR, Zhang T and Zanni MT. Two-dimensional sum-frequency generation (2D SFG) spectroscopy: Summary of principles and its application to amyloid fiber monolayers. Faraday Discussions, 2015, 177, 493-505.

Ghosh A, Wang J, Moroz Y, Korendovych I, Zanni M, DeGrado WF, Gai, F and Hochstrasser RM. 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. Journal of Chemical Physics, 2014, 140, 235105.

Pazos IM, Ghosh A, Tucker MJ, Gai, F. Ester Carbonyl Vibration as a Sensitive Probe of Protein Local Electric Field. Angewandte Chemie International Edition, 2014, 126, 6194 –6198.

Ghosh A, Tucker MJ, Gai, F. 2D IR Spectroscopy of Histidine: Probing Sidechain Structure and Dynamics via Backbone Amide I Vibration. Journal of Physical Chemistry B, 2014, 118, 7799–7805.

Chuntonov L, Kuroda DG, Ghosh A, Ma JQ, Hochstrasser RM. Quantum Beats and Coherence Decay in Degenerate States Split by Solvation. Journal of Physical Chemistry Letters, 2013, 4, 1866-1871.